Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death – Chen CC et al. – Journal of Ethnopharmacology 117 (2008) 483–490

  • Article (title, authors, journal, year and pages): Fructus Corni suppresses hepatic gluconeogenesis related gene transcription,enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death – Chen CC et al. – Journal of Ethnopharmacology 117 (2008) 483–490
  • Plant (scientific name of the main plant): Cornus officinalis
  • WP4 reference member: Prof. Enrica Bosisio
  • Plant/s used (if a phytocomplex from one or more plants are used):
  • Formula used (if a phytocomplex from a formula is used):
  • Purified molecules used (if single compounds are used): loganin, ursolic acid
  • Disease/s: diabetes
  • molecular target/s and/or mechanisms investigated: reduced PEPCK gene expression for hepatic gluconeogenesis, β-cell protection against toxic challenge, insulin secretion enhancement in hyperglycemic condition
  • General quality score (mean ± SD): 52 ±11
  • Relevance score for TCM research (mean ± SD): 4,6 ±1,5

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