WP5 – Pharmacology in vivo

Our overall objective is to develop collaboration between European and Chinese Specialist in Biomedical Research and/or Chinese Herbal Medicines (CHM) in order to:

  • Give directions for the application of functional genomics to in vivo studies of CHM
  • Optimise research opportunities on CHM through planning coordinated efforts for future directions
  • Establish best practice for animal studies of CHM in the EU
  • Link together European and Chinese experts in the field

Interaction with other WPs:

WP5 is actively collaborating with WP4 (in vitro studies), WP3 (toxicology) and WP6 (clinical studies). In fact, participants in our WP5 are also participants in other WPs, including WP3 and WP4.

Potential WP impact:

WP4 and WP5 are defined as the core value of the project, since the therapeutic values of CHM should be evaluates using in vivo and in vitro settings. Moreover, in coordination with WP6, the pharmacology of CHM in animal models and patient will be discussed. Guidelines proposed by WP5 will significantly promote the understanding of TCM. Drugs should be first tested in animal models before moving on clinical trials. Diagnosis in patients as well as in animal models in a TCM way “Zhenghou” might be difficult but it will be critical for TCM efficacy evaluation. WP5 will deliver guidelines for non conventional diagnosis methods in animal models. Functional genomic studies to be applied to animal models of TCM will be another novel and relevant deliverable for our WP.

WP5 Members:
Beneficiary members

Prof. Francisco Javier Lucio Cazaña (WP5 Coordinator, University of Alcala, Spain)

Dr. Maria Laura Garcia Bermejo (WP4 Assistant Coordinator, University Hospital Ramón y Cajal, Spain)

Prof. Bruce Hendry (King’s College London, UK)

Dr. Qihe Xu (King’s College London, UK)

Prof. Peter Hylands (King’s College London, UK)

Dr. Joelle Nortier (Université Libre de Bruxelles, Belgium)

Prof. Jifeng Wang (Beijing University of Chinese Medicine)

Ms. Noelia Tejedor (University of Alcala, Spain)

Dr. Ana Belén Fernández Martínez (University of Alcala, Spain)

Non-beneficiary members

Prof. Sue Watson (WP5 Deputy Coordinator,  University of Nottingham, UK)

Prof. Ping Li (China-Japan Friendship Hospital, China)

Prof. Liping Zhao (Shanghai Jiaotong University, China)

Prof. Xiaodong Cheng (Shanghai University of Traditional Chinese Medicine, China)

Dr. William Weiguo Jia (Shanghai Innovation Research Center of Traditional Medicine, China)

Dr. Huige Li (Johannes Gutenberg University, Germany)

Ms. Gemma Olmos Centenera (University of Alcalá, Spain)

Prof. Y. James Kang (University of Louisville, USA)

Dr. Rajendra Kumari (University of Nottingham, UK)

Prof. Zuguang Ye (China Academy of Chinese Medical Sciences, China)

Dr. Xuebin Dong (King’s College London, UK)

WP5 Contact:

Dr. Maria Laura Garcia Bermejo

WP5 Assistant Coordinator

Department of Pathology

University Hospital Ramón y Cajal

Carretera de Colmenar, km 9,100

28034 Madrid

Spain

Tel:  +34 91 336 80 75

Fax: +34 91 336 90 16

E-mail: mgarciab.hrc@salud.madrid.org

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