Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression – Chen N-H.-Pharmacological Reports 2010 – 62 – 150-163 | Good Practice in Traditional Chinese Medicine

Article (title, authors, journal, year and pages): Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression – Chen N-H.-Pharmacological Reports 2010 – 62 – 150-163
Plant (scientific name of the main plant): Ganoderma lucidum
WP4 reference member: Prof. Laura Maria Garcia Bermejo
Plant/s used (if a phytocomplex from one or more plants are used):
Formula used (if a phytocomplex from a formula is used):
Purified molecules used (if single compounds are used): ganoderic acid T
Disease/s: cancer
molecular target/s and/or mechanisms investigated: inhibition of proliferation, inhibition of adhesion to ECM, induction of homotypic aggregation, inhibition of cell migration, down-regulation of the expression of matrix metalloproteinase-9(MMP-9), inducible nitric oxide synthase (iNOS), and urokinase-type plasminogen activator (uPA).
General quality score (mean ± SD): article not meeting inclusion criteria for evaluation
Relevance score for TCM research (mean ± SD): article not meeting inclusion criteria for evaluation

Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression – Chen N-H.-Pharmacological Reports 2010 – 62 – 150-163